The show starred Jonny Lee Miller in the title role of attorney Eli Stone. In the first episode, Stone is discovered to have an inoperable brain aneurysm which is causing hallucinations. His acupuncturist, Dr. Chen, suggests that his hallucinations are actually divinely inspired visions of the future. These visions often foreshadowed future cases and events, including an impending earthquake.

Eli Stone is an American television comedy-drama created by Greg Berlanti and Marc Guggenheim, who also served as executive producers alongside Ken Olin who directed the pilot, with Melissa Berman producing.

Characters
Jonny Lee Miller - Eli Stone (Young Eli is played by Justin Lieberman)
Eli Stone is a successful attorney in San Francisco who is diagnosed with an inoperable brain aneurysm which is causing hallucinations. The hallucinations cause Eli to become alienated by his peers and soon his life takes a detour. Despite the fact that he is not religious, he takes his hallucinations as signs, helping people in accepting lawsuits in hopes of bettering their lives.

Natasha Henstridge - Taylor Wethersby
Taylor Wethersby is Eli's ex-fiance who is also an attorney. She formerly works in another company, and later joins in Eli's firm after they broke up. Although taken aback by Eli's episodes of hallucinations, she is determined to help him at any means. She is the daughter of Jordan Wethersby, the head of Wethersby, Posner & Klein.

Loretta Devine - Patti Dellacroix
Patti is Eli's helpful and sassy assistant. She considers Eli as a dear friend of hers and she is always blatantly honest to Eli.

Matt Letscher - Dr. Nathan Stone
Nathan is Eli's caring elder brother who is a doctor. He is the first who discovered Eli's conditions and he is also skeptical about his visions. Nathan dated Beth, a girl who Eli lost his virginity to in college after Eli introduced each other at his engagement party.

Sam Jaeger - Matt Dowd
Matt is Eli's co-worker and rival in the law firm. He is described as sarcastic, arrogant and having a frat-boy personality.

James Saito - Dr. Chen
Dr. Chen is an acupuncturist who explains Eli's conditions as a prophetical message. He helps Eli to analyze the visions Eli has and advises Eli to pursue them. He studied acupuncture in Beijing as well as holistic medicine. It is revealed that he is not a Chinese immigrant, and the "Dr. Chen" is merely an act so he will be taken seriously because, "No one trusts an acupuncturist from New Jersey". He once worked for Eli's father, who told him once that he would repay a favor by helping his son (Eli) someday.

Julie Gonzalo - Maggie Dekker
Maggie is a junior attorney who is ambitious and enthusiastic to her work. Much to Eli's dismay, she often assists him in his cases in hopes of moving up the career ladder. She is considered a religious person who is the first person to believe in Eli's visions without hesitations. She was engaged to Scott, who is in Eli's visions of the earthquake.

Jason George - Keith Bennett
Keith is a criminal law attorney who sued an employer for racism. After Keith lost the lawsuit, Jordan hired him as he saw Keith's potential.

Victor Garber - Jordan Wethersby
Jordan is the co-owner of the firm and Taylor's father. He is often skeptical of Eli's imaginations. However, He is a father figure to Eli and represented Eli when Eli is prosecuted for ineligibility to perform his work.